Wissenschaftliche Artikel

Coy, J. F.
EDIM-TKTL1/Apo10 Blood Test. An Innate Immune System Based Liquid Biopsy for the Early Detection, Characterization and Targeted Treatment of Cancer.
Int J Mol Sci. 2017, 18(4). | doi: 10.3390/ijms18040878. [PubMed]

No. 57

Diaz-Moralli, S.; Aguilar, E.; Marin, S.; Coy, J. F.; Dewerchin, M.; Antoniewicz, M. R.; Meca-Cortés, O.; Notebaert, L.; Ghesquière, B.; Eelen, G.; Thomson, T. M.; Carmeliet, P.; Cascante, M.
A key role for transketolase-like 1 in tumor metabolic reprogramming.
Oncotarget. 2016, 7(32): 51875–51897. | doi: 10.18632/oncotarget.10429. [PubMed]

No. 56

Grimm, M.; Feyen, O.; Coy, J. F.; Hofmann, H.; Teriete, P.; Reinert, S.
Analysis of circulating CD14+/CD16+ monocyte-derived macrophages (MDMs) in the peripheral blood of patients with oral squamous cell carcinoma.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2016, 121(3): 301–306. | doi: 10.1016/j.oooo.2015.10.024. [PubMed]

No. 55

Karstedt, S. von; Conti, A.; Nobis, M.; Montinaro, A.; Hartwig, T.; Lemke, J.; Legler, K.; Annewanter, F.; Campbell, A. D.; Taraborrelli, L.; Grosse-Wilde, A.; Coy, J. F.; El-Bahrawy, M. A.; Bergmann, F.; Koschny, R.; Werner, J.; Ganten, T. M.; Schweiger, T.; Hoetzenecker, K.; Kenessey, I.; Hegedüs, B.; Bergmann, M.; Hauser, C.; Egberts, J.-H.; Becker, T.; Röcken, C.; Kalthoff, H.; Trauzold, A.; Anderson, K. I.; Sansom, O. J.; Walczak, H.
Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis.
Cancer Cell. 2015, 27(4): 561–573. | doi: 10.1016/j.ccell.2015.02.014. [PubMed]

No. 54

Rieger, J.; Bähr, O.; Maurer, G. D.; Hattingen, E.; Franz, K.; Brucker, D.; Walenta, S.; Kämmerer, U.; Coy, J. F.; Weller, M.; Steinbach, J. P.
ERGO. A pilot study of ketogenic diet in recurrent glioblastoma.
Int J Oncol. 2014, 44(6): 1843–1852. | doi: 10.3892/ijo.2014.2382. [PubMed]

No. 53

Japink, D.; Nap, M.; Sosef, M. N.; Nelemans, P. J.; Coy, J. F.; Beets, G.; Meyenfeldt, M. F. von; Leers, M. P. G.
Reproducibility studies for experimental epitope detection in macrophages (EDIM).
J Immunol Methods. 2014, 407: 40–47. | doi: 10.1016/j.jim.2014.03.018. [PubMed]

No. 52

Grimm, M.; Schmitt, S.; Teriete, P.; Biegner, T.; Stenzl, A.; Hennenlotter, J.; Muhs, H.-J.; Munz, A.; Nadtotschi, T.; König, K.; Sänger, J.; Feyen, O.; Hofmann, H.; Reinert, S.; Coy, J. F.
A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells.
BMC Cancer. 2013, 13: 569. | doi: 10.1186/1471-2407-13-569. [PubMed]

No. 51

Bentz, S.; Cee, A.; Endlicher, E.; Wojtal, K. A.; Naami, A.; Pesch, T.; Lang, S.; Schubert, P.; Fried, M.; Weber, A.; Coy, J. F.; Goelder, S.; Knüchel, R.; Hausmann, M.; Rogler, G.
Hypoxia induces the expression of transketolase-like 1 in human colorectal cancer.
Digestion. 2013, 88(3): 182–192. | doi: 10.1159/000355015. [PubMed]

No. 50

Mohan Kumar, D.; Yamaguchi, M.; Miura, K.; Lin, M.; Los, M.; Coy, J. F.; Rikihisa, Y.
Ehrlichia chaffeensis uses its surface protein EtpE to bind GPI-anchored protein DNase X and trigger entry into mammalian cells.
PLoS Pathog. 2013, 9(10): e1003666. | doi: 10.1371/journal.ppat.1003666. [PubMed]

No. 49

Jansen, N.; Coy, J. F.
Diagnostic use of epitope detection in monocytes blood test for early detection of colon cancer metastasis.
Future Oncol. 2013, 9(4): 605–609. | doi: 10.2217/fon.13.8. [PubMed]

No. 48

Feyen, O.; Coy, J. F.; Prasad, V.; Schierl, R.; Saenger, J.; Baum, R. P.
EDIM-TKTL1 blood test. A noninvasive method to detect upregulated glucose metabolism in patients with malignancies.
Future Oncol. 2012, 8(10): 1349–1359. | doi: 10.2217/fon.12.98. [PubMed]

No. 47

Fritz, P.; Coy, J. F.; Mürdter, T. E.; Ott, G.; Alscher, M. Dominik; Friedel, G.
TKTL-1 expression in lung cancer.
Pathol Res Pract. 2012, 208(4): 203–209. | doi: 10.1016/j.prp.2012.01.007. [PubMed]

No. 46

Bentz, S.; Pesch, T.; Wolfram, L.; Vallière, C. de; Leucht, K.; Fried, M.; Coy, J. F.; Hausmann, M.; Rogler, G.
Lack of transketolase-like (TKTL) 1 aggravates murine experimental colitis.
Am J Physiol Gastrointest Liver Physiol. 2011, 300(4): G598-607. | doi: 10.1152/ajpgi.00323.2010. [PubMed]

No. 45

Mitschke, L.; Parthier, C.; Schröder-Tittmann, K.; Coy, J.; Lüdtke, S.; Tittmann, K.
The crystal structure of human transketolase and new insights into its mode of action.
J Biol Chem. 2010, 285(41): 31559–31570. | doi: 10.1074/jbc.M110.149955. [PubMed]

No. 44

Demetrius, L. A.; Coy, J. F.; Tuszynski, J. A.
Cancer proliferation and therapy. The Warburg effect and quantum metabolism.
Theor Biol Med Model. 2010, 7: 2. | doi: 10.1186/1742-4682-7-2. [PubMed]

No. 43

Xu, X.; Zur Hausen, A.; Coy, J. F.; Löchelt, M.
Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells.
Int J Cancer. 2009, 124(6): 1330–1337. | doi: 10.1002/ijc.24078. [PubMed]

No. 42

Zerilli, M.; Amato, M. C.; Martorana, A.; Cabibi, D.; Coy, J. F.; Cappello, F.; Pompei, G.; Russo, A.; Giordano, C.; Rodolico, V.
Increased expression of transketolase-like-1 in papillary thyroid carcinomas smaller than 1.5 cm in diameter is associated with lymph-node metastases.
Cancer. 2008, 113(5): 936–944. | doi: 10.1002/cncr.23683. [PubMed]

No. 41

Völker, H.-U.; Hagemann, C.; Coy, J.; Wittig, R.; Sommer, S.; Stojic, J.; Haubitz, I.; Vince, G. Hamilton; Kämmerer, U.; Monoranu, C.-M.
Expression of transketolase-like 1 and activation of Akt in grade IV glioblastomas compared with grades II and III astrocytic gliomas.
Am J Clin Pathol. 2008, 130(1): 50–57. | doi: 10.1309/6H9844AMMET82DBJ. [PubMed]

No. 40

Otto, C.; Kaemmerer, U.; Illert, B.; Muehling, B.; Pfetzer, N.; Wittig, R.; Voelker, H. Ullrich; Thiede, A.; Coy, J. F.
Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides.
BMC Cancer. 2008, 8: 122. | doi: 10.1186/1471-2407-8-122. [PubMed]

No. 39

Langbein, S.; Frederiks, W. M.; Zur Hausen, A.; Popa, J.; Lehmann, J.; Weiss, C.; Alken, P.; Coy, J. F.
Metastasis is promoted by a bioenergetic switch. New targets for progressive renal cell cancer.
Int J Cancer. 2008, 122(11): 2422–2428. | doi: 10.1002/ijc.23403. [PubMed]

No. 38

Wittig, R.; Coy, J. F.
The role of glucose metabolism and glucose-associated signalling in cancer.
Perspect Medicin Chem. 2008, 1: 64–82. [PubMed]

No. 37

Wentzensen, N.; Coy, J. F.; Knaebel, H.-P.; Linnebacher, M.; Wilz, B.; Gebert, J.; Knebel Doeberitz, M. von
Expression of an endogenous retroviral sequence from the HERV-H group in gastrointestinal cancers.
Int J Cancer. 2007, 121(7): 1417–1423. | doi: 10.1002/ijc.22826. [PubMed]

No. 36

Földi, M.; Stickeler, E.; Bau, L.; Kretz, O.; Watermann, D.; Gitsch, G.; Kayser, G.; Zur Hausen, A.; Coy, J. F.
Transketolase protein TKTL1 overexpression. A potential biomarker and therapeutic target in breast cancer.
Oncol Rep. 2007, 17(4): 841–845. [PubMed]

No. 35

Krockenberger, M.; Honig, A.; Rieger, L.; Coy, J. F.; Sutterlin, M.; Kapp, M.; Horn, E.; Dietl, J.; Kammerer, U.
Transketolase-like 1 expression correlates with subtypes of ovarian cancer and the presence of distant metastases.
Int J Gynecol Cancer. 2007, 17(1): 101–106. | doi: 10.1111/j.1525-1438.2007.00799.x. [PubMed]

No. 34

Staiger, W. I.; Coy, J. F.; Grobholz, R.; Hofheinz, R.-D.; Lukan, N.; Post, S.; Schwarzbach, M. H.; Willeke, F.
Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer.
Oncol Rep. 2006, 16(4): 657–661. [PubMed]

No. 33

Langbein, S.; Zerilli, M.; Zur Hausen, A.; Staiger, W.; Rensch-Boschert, K.; Lukan, N.; Popa, J.; Ternullo, M. P.; Steidler, A.; Weiss, C.; Grobholz, R.; Willeke, F.; Alken, P.; Stassi, G.; Schubert, P.; Coy, J. F.
Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival. Warburg effect reinterpreted.
Br J Cancer. 2006, 94(4): 578–585. | doi: 10.1038/sj.bjc.6602962. [PubMed]

No. 32

Coy, J. F.; Dressler, D.; Wilde, J.; Schubert, P.
Mutations in the transketolase-like gene TKTL1. Clinical implications for neurodegenerative diseases, diabetes and cancer.
Clin Lab. 2005, 51(5-6): 257–273. [PubMed]

No. 31

Koesters, R.; Linnebacher, M.; Coy, J. F.; Germann, A.; Schwitalle, Y.; Findeisen, P.; Knebel Doeberitz, M. von
WT1 is a tumor-associated antigen in colon cancer that can be recognized by in vitro stimulated cytotoxic T cells.
Int J Cancer. 2004, 109(3): 385–392. | doi: 10.1002/ijc.11721. [PubMed]

No. 30

Targett-Adams, P.; Chambers, D.; Gledhill, S.; Hope, R. Graham; Coy, J. F.; Girod, A.; McLauchlan, J.
Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein.
J Biol Chem. 2003, 278(18): 15998–16007. | doi: 10.1074/jbc.M211289200. [PubMed]

No. 29

Götte, K.; Riedel, F.; Schäfer, C.; Coy, J. F.; Hörmann, K.
Genetic discordance between primary tumours and metastases of head and neck cancer detected by microsatellite analysis.
Oncol Rep. 2002, 9(4): 829–834. [PubMed]

No. 28

Sadowski-Debbing, K.; Coy, J. F.; Mier, W.; Hug, H.; Los, M.
Caspases–their role in apoptosis and other physiological processes as revealed by knock-out studies.
Arch Immunol Ther Exp (Warsz ). 2002, 50(1): 19–34. [PubMed]

No. 27

Coy, J. F.; Wiemann, S.; Bechmann, I.; Bächner, D.; Nitsch, R.; Kretz, O.; Christiansen, H.; Poustka, A.
Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms.
Gene. 2002, 290(1-2): 73–94. [PubMed]

No. 26

Götte, K.; Riedel, F.; Neubauer, J.; Schäfer, C.; Coy, J. F.; Hörmann, K.
The relationship between allelic imbalance on 17p, p53 mutation and p53 overexpression in head and neck cancer.
Int J Oncol. 2001, 19(2): 331–336. [PubMed]

No. 25

Finzer, P.; Soto, U.; Delius, H.; Patzelt, A.; Coy, J. F.; Poustka, A.; Zur Hausen, H.; Rösl, F.
Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells. The role of the chromatin structure and AP-1 composition.
Oncogene. 2000, 19(29): 3235–3244. | doi: 10.1038/sj.onc.1203643. [PubMed]

No. 24

Los, M.; Neubüser, D.; Coy, J. F.; Mozoluk, M.; Poustka, A.; Schulze-Osthoff, K.
Functional characterization of DNase X, a novel endonuclease expressed in muscle cells.
Biochemistry. 2000, 39(25): 7365–7373. [PubMed]

No. 23

Götte, K.; Riedel, F.; Coy, J. F.; Spahn, V.; Hörmann, K.
Salivary gland carcinosarcoma. Immunohistochemical, molecular genetic and electron microscopic findings.
Oral Oncol. 2000, 36(4): 360–364. [PubMed]

No. 22

Götte, K.; Hadaczek, P.; Coy, J. F.; Wirtz, H. W.; Riedel, F.; Neubauer, J.; Hörmann, K.
Fhit expression is absent or reduced in a subset of primary head and neck cancer.
Anticancer Res. 2000, 20(2A): 1057–1060. [PubMed]

No. 21

Götte, K.; Riedel, F.; Schäfer, C.; Coy, J.; Hörmann, K.
Cylindrical cell carcinomas of the paranasal sinuses do not show p53 alterations but loss of heterozygosity at 3p and 17p.
Int J Cancer. 2000, 85(5): 740–742. [PubMed]

No. 20

Mollenhauer, J.; Holmskov, U.; Wiemann, S.; Krebs, I.; Herbertz, S.; Madsen, J.; Kioschis, P.; Coy, J. F.; Poustka, A.
The genomic structure of the DMBT1 gene. Evidence for a region with susceptibility to genomic instability.
Oncogene. 1999, 18(46): 6233–6240. | doi: 10.1038/sj.onc.1203071. [PubMed]

No. 19

Coy, J. F.; Sedlacek, Z.; Bächner, D.; Delius, H.; Poustka, A.
A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3″-untranslated region of the methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression.
Hum Mol Genet. 1999, 8(7): 1253–1262. [PubMed]

No. 18

Li-Weber, M.; Laur, O.; Hekele, A.; Coy, J.; Walczak, H.; Krammer, P. H.
A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation.
Eur J Immunol. 1998, 28(8): 2373–2383. | doi: 10.1002/(SICI)1521-4141(199808)28:08<2373::AID-IMMU2373>3.0.CO;2-T. [PubMed]

No. 17

Seither, P.; Coy, J. F.; Pouska, A.; Grummt, I.
Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I.
Mol Gen Genet. 1997, 255(2): 180–186. [PubMed]

No. 16

Zewe, M.; Rybak, S. M.; Dübel, S.; Coy, J. F.; Welschof, M.; Newton, D. L.; Little, M.
Cloning and cytotoxicity of a human pancreatic RNase immunofusion.
Immunotechnology. 1997, 3(2): 127–136. [PubMed]

No. 15

Laporte, J.; Hu, L. J.; Kretz, C.; Mandel, J. L.; Kioschis, P.; Coy, J. F.; Klauck, S. M.; Poustka, A.; Dahl, N.
A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast.
Nat Genet. 1996, 13(2): 175–182. | doi: 10.1038/ng0696-175. [PubMed]

No. 14

Sandoval, N.; Bauer, D.; Brenner, V.; Coy, J. F.; Drescher, B.; Kioschis, P.; Korn, B.; Nyakatura, G.; Poustka, A.; Reichwald, K.; Rosenthal, A.; Platzer, M.
The genomic organization of a human creatine transporter (CRTR) gene located in Xq28.
Genomics. 1996, 35(2): 383–385. | doi: 10.1006/geno.1996.0373. [PubMed]

No. 13

Kioschis, P.; Rogner, U. C.; Pick, E.; Klauck, S. M.; Heiss, N.; Siebenhaar, R.; Korn, B.; Coy, J. F.; Laporte, J.; Liechti-Gallati, S.; Poustka, A.
A 900-kb cosmid contig and 10 new transcripts within the candidate region for myotubular myopathy (MTM1).
Genomics. 1996, 33(3): 365–373. | doi: 10.1006/geno.1996.0212. [PubMed]

No. 12

Coy, J. F.; Dübel, S.; Kioschis, P.; Thomas, K.; Micklem, G.; Delius, H.; Poustka, A.
Molecular cloning of tissue-specific transcripts of a transketolase-related gene. Implications for the evolution of new vertebrate genes.
Genomics. 1996, 32(3): 309–316. | doi: 10.1006/geno.1996.0124. [PubMed]

No. 11

Wilgenbus, K. K.; Coy, J. F.; Mincheva, A.; Nicolai, H.; Solomon, E.; Lichter, P.; Poustka, A.
Ordering of 66 STSs along the entire short arm of human chromosome 17 and chromosome assignment of a transcribed sequence (FMR1L2) homologous to FMR1.
Cytogenet Cell Genet. 1996, 73(3): 240–243. | doi: 10.1159/000134347. [PubMed]

No. 10

Coy, J. F.; Velhagen, I.; Himmele, R.; Delius, H.; Poustka, A.; Zentgraf, H.
Isolation, differential splicing and protein expression of a DNase on the human X chromosome.
Cell Death Differ. 1996, 3(2): 199–206. [PubMed]

No. 9

Coy, J. F.; Sedlacek, Z.; Bächner, D.; Hameister, H.; Joos, S.; Lichter, P.; Delius, H.; Poustka, A.
Highly conserved 3′ UTR and expression pattern of FXR1 points to a divergent gene regulation of FXR1 and FMR1.
Hum Mol Genet. 1995, 4(12): 2209–2218. [PubMed]

No. 8

Strand, D.; Unger, S.; Corvi, R.; Hartenstein, K.; Schenkel, H.; Kalmes, A.; Merdes, G.; Neumann, B.; Krieg-Schneider, F.; Coy, J. F.
A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain.
Oncogene. 1995, 11(2): 291–301. [PubMed]

No. 7

Döhner, H.; Fischer, K.; Bentz, M.; Hansen, K.; Benner, A.; Cabot, G.; Diehl, D.; Schlenk, R.; Coy, J.; Stilgenbauer, S.
p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias.
Blood. 1995, 85(6): 1580–1589. [PubMed]

No. 6

Kioschis, P.; Gong, W.; Rogner, U. C.; Wilke, K.; Manca, A.; Coy, J. F.; Poustka, A.
Cosmid Contigs in Xq27.3-Xqter.
Cytogenet Cell Genet. 1994, 67: 355

No. 5

Lawrence, B. J.; Schwabe, W.; Kioschis, P.; Coy, J. F.; Poustka, A.; Brennan, M. B.; Hochgeschwender, U.
Rapid identification of gene sequences for transcriptional map assembly by direct cDNA screening of genomic reference libraries.
Hum Mol Genet. 1994, 3(11): 2019–2023. [PubMed]

No. 4

Coy, J. F.; Kioschis, P.; Sedlacek, Z.; Poustka, A.
Identification of tissue-specific expressed sequences in human band Xq28 with complex pig cDNA probes.
Mamm Genome. 1994, 5(3): 131–137. [PubMed]

No. 3

Kioschis, P.; Coy, J. F.; Gong, W.; Rogner, U.; Bohn, E.; Poustka, A.
Towards a clone and transcript map of Xq27.3-qter.
Cytogenet Cell Genet. 1993, 64: 180

No. 2

Sedlacek, Z.; Korn, B.; Konecki, D. S.; Siebenhaar, R.; Coy, J. F.; Kioschis, P.; Poustka, A.
Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection.
Hum Mol Genet. 1993, 2(11): 1865–1869. [PubMed]

No. 1