EDIM technologyEpitope detection in monocytes– flow cytometric blood analysis as a kind of liquid biopsy that uses the innate immune system. By means of flow cytometry, macrophages in the blood can be analyzed and examined for the presence of selected biomarkers. The method thus allows the development of various minimally invasive blood tests for the diagnosis and early detection of a wide variety of diseases. |
Background:
Activated macrophages, the so-called “scavenger cells” of the innate immune system, have the ability to recognize, enclose and digest undesired cell structures such as bacteria, parasites and tumor cells (phagocytosis). To do this, they penetrate tissue, take up unwanted cells or cell fragments and then return to the blood. By digesting the cell material inside the macrophages, small molecular structures (epitopes) are released, which the macrophages incorporate into their surface membrane and “present” to other immune cells. This activates further cells of the immune system to actively fight the unwanted cells. On the other hand, these epitopes can be used diagnostically as biomarkers.
Depending on the type of previously phagocytized cells or cell fragments, macrophages in blood samples contain very specific epitopes whose detection indicates certain undesired cells such as tumor cells.
- Protected by patent: EP2986985A2
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PanTum Detect universal cancer blood testEarly detection of tumorsBased on the EDIM technology, an innovative unique blood test was developed, which uses the markers Apo10 and TKTL1, which I discovered, for the early detection of tumors. This allows not only the detection of cancer cells, but also of tumors at an early stage and ensures a timely start of treatment if performed regularly. |
Background:
Furthermore, the test can be used to characterize the tumor with regard to aggressiveness, invasiveness, metastasis potential and resistance to chemo-, radiation- and targeted therapies, thus supporting the optimal choice of therapy.
Benfo-OxythiamineInhibitor against chemo-resistant cancer cellsInhibitors of the TKTL1 metabolism provide the basis for new therapeutic concepts that also make it possible to combat chemo-resistant cancer cells as well as cancer cells that are resistant to targeted therapies such as imatinib and sorafenib. The thiamine (vitamin B1) derivative benfo-oxythiamine is the first potential inhibitor of this resistance-promoting metabolism. |
The active ingredient is a prodrug of oxythiamine, which blocks thiamin-dependent enzymes such as TKTL1 and transketolase (TKT) and makes chemo-resistant cancer cells sensitive to therapy again.
- Protected by patent: EP2256500B1
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Drinks with lactateLow-carbohydrate, high-fat drinks to support therapyDietetic drinks with a high fat but low carbohydrate content provide the body with high-quality energy without promoting the sugar-dependent TKTL1 metabolism. Lactate supports the mild deacidification of the disease- and therapy-induced hyperacidity of cancer patients by degrading it in the liver to the buffer base bicarbonate. |
Keto-Drink (formerly Coy Complete) is a reimbursable dietary drink with a ketogenic nutrient profile to support classical cancer therapy and for the dietary management of tumor cachexia. Thanks to its special composition, it allows ketosis to be reached easily and quickly shortly before chemotherapy or radiotherapy. The aim of this metabolic preparation is to minimize the side effects caused by the therapy, to improve the tolerability of the therapy and to sensitize the cancer cells to the subsequent chemotherapy and radiotherapy.
Laktat-Drink is a highly fermented mixed milk drink with low carbohydrate and increased lactate content.
- Protected by patent: EP1972209B1
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Functional chocolate productsFor intelligent chocolate enjoymentThe basis of these unique chocolate products is the use of natural, low-glycemic and tooth-friendly sugars isomaltulose & galactose instead of conventional sugar, thus avoiding blood sugar peaks and protecting the teeth at the same time. Combined with other functional ingredients, the chocolates promise intelligent enjoyment at the highest level. |
- Isomaltulose: natural, tooth-friendly sweetness with low blood sugar effect
- Galactose: low-glycemic energy source
- Tocotrienols: antioxidative cell protection through unsaturated vitamin E
- Omega-3: DHA & EPA support for heart and brain
- Inulin: for a high fibre content and lower blood sugar effect
- Protected by patent: EP2590514B1
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Premium Energy DrinksNatural refreshment with functional ingredientsThe exclusive refreshment drinks combine fast energy with blood sugar friendly sugars, mental strengthening with selected plant extracts and natural refreshment thanks to exquisite plant aromas. |
This is what makes soft drinks so special:
- The combination of natural low-glycemic and tooth-friendly sugars avoids blood sugar peaks and supports tooth mineralization.
- Valuable polyphenols and exquisite extracts of lemon balm and rose root provide new physical and mental energy.
- Natural aromas from various plant extracts ensure a pleasant taste.
- Mild gluconic acid, little caffeine and no use of fructose promise a well-tolerated pleasure.
- Protected by patent: EP2590514B1
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